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. Author manuscript; available in PMC: 2012 Mar 2.
Published in final edited form as: Cell Metab. 2011 Mar 2;13(3):320–330. doi: 10.1016/j.cmet.2011.02.001

Figure 2.

Figure 2

(A) Increased phosphorylation of p44/42-MAPK in caudal DVC tissue lysates following 4th icv Ex-4 (0.3μg) administration. Representative immunoblots for phosphorylated and total p44/42-MAPK are shown. * = P< 0.05 from aCSF. Cumulative chow intake (B) and 24h body weight change (C) following 4th icv delivery of the MEK inhibitor U0126 (2μg) or Ex-4 (0.2μg) alone or in combination, counterbalanced with vehicle/vehicle (DMSO/aCSF). Data are mean ± SEM. * = P< 0.05 from vehicle/vehicle. † = P< 0.05 from vehicle/Ex-4.