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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Cancer Res. 2011 Feb 9;71(7):2445–2454. doi: 10.1158/0008-5472.CAN-10-2628

Figure 5.

Figure 5

TNF-α is necessary for phthisis but not rejection of intraocular Ad5E1 clone 2.1 tumors. A, clone 2.1 tumor cells, I/CB cells, and corneal endothelial cells were incubated in medium alone or medium containing TNF-α for 48 hours. Cytotoxicity was determined by LDH release. B, Ad5E1 clone 2.1 tumor cells were injected into the AC of TNF-α KO mice or WT C57BL/6 mice. C, photograph of nonphthisical rejection of Ad5E1 clone 2.1. D, AC injection of clone 2.1 tumor cells in WT, TNF-α KO, TNFR1 KO, and TNFR2 KO mice. Experiments were performed twice with similar results. n = 5 mice per group.