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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Cancer Res. 2011 Feb 9;71(7):2445–2454. doi: 10.1158/0008-5472.CAN-10-2628

Figure 6.

Figure 6

T cells are the source of TNF-α. A, expression of TNF-α mRNA from tumor-bearing WT and IFN-γ KO eyes was determined by qPCR and compared with a non-tumor-bearing eye. B, T cells harvested from tumor rejector mice were unstimulated or were stimulated with tumor antigen (TA)-pulsed APCs or with anti-CD3/CD28 beads. Secretion of TNF-α was determined by ELISA. C, T cells from C57BL/6 and TNF-α KO tumor rejector mice were adoptively transferred to SCID or IFN-γ KO mice and recipient mice were injected with clone 2.1 tumor cells in the AC. n = 9 or 10 mice in each group. D, percentage of animals that underwent nonphthisical intraocular tumor rejection in C. Histologic sections of eyes that underwent nonphthisical (E) or phthisical (F) tumor rejection.