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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Can J Anaesth. 2011 Jan 7;58(2):191–205. doi: 10.1007/s12630-010-9419-9

Table 2.

MWC Coagonist Model Parameters for Wild-Type and Mutant GABAA Receptors Activated with GABA +/- Etomidate

Receptor L0 KG(μM) c KE (μM) d
α1β2γ2L 25,000 70 0.0019 40 0.0077
α1M236Wβ2γ2L 6.2 51 0.021 24 0.18
α1β2M286Wγ2L 31 32 0.029 NA NA
α1β2N265Sγ2L 25,000 68 0.0018 88 0.038
α1β2N265Mγ2L 50,000 59 0.0019 NA NA

The allosteric model parameters are described in the legend to Figure 1. L0 was estimated as described in Desai et al (66). Parameters were fit by non-linear least squares as described in Desai et al (66).