Table 3.
Pairs of Variant Alleles Observed to Have Suggestively Significant Association with the Severity of Atherosclerosis as Represented by Gensini Scores
| Marker I (background) | Marker 2 (additional variant) | Q1 vs Q5 | |
|---|---|---|---|
| combined gender | females only | ||
| apoE (3/4, 4/4) | CBS278thr/68-bp I | ▴* | — |
| apoCIII (−625)del or apoCIII (−455)C | apoB Ile-71 | — | ▾* |
| apoCIII 3206G | apoB Ile-71 | — | ▾* |
| PON 192arg | apoB Ile-71 | — | ▾* |
| PON 192arg | ACE (I/D, D/D) | ▴* | — |
| ACE (I/D, D/D) | apoB Ile-71 | — | ▾** |
| ATIIR 1166C | AGT Thr-235 | — | ▴* |
| ATIIR 1166C | CBS Thr278/68-bp I | — | ▾* |
| AGT 235thr | apoB Ile-71 | — | ▾** |
| AGT 235thr | ATIIR 1166C | — | ▴* |
| CBS 278thr/68-bp I | apoCIII (−625)del or apoCIII (−455)C | — | ▴* |
| CBS 278thr/68-bp I | apoCIII (−428T)C | — | ▴* |
| GPIIIa 33pro | ATIIR 1166C | ▴* | ▴* |
| fibrinogen (−455)A | apoB Ile-71 | — | ▾* |
| ▴ Predisposing: | 3 | 5 | |
| ▾ Protective: | 0 | 7 | |
For each pair listed, the odds ratio corresponds to the risk associated with carrying a second variant allele (relative to the more frequent allele of Marker 2) within the set of individuals who carried a first variant allele (the background marker). A total of 15 markers were analyzed in this pairwise manner. Both combined-gender and female-only quintiles were evaluated, as described in Methods. (**) P < 0.01; (*) 0.001 ≤ P < 0.05; (—) P > 0.05.