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Distributive extension of telomere by telomerase in Hela cells with overexpressed hTERT. (A) A partial inhibition of telomerase activity by GRN163L in cells with overexpressed telomerase. Telomerase activity was assayed by TRAP. (B) Telomeres are elongated by overexpressed telomerase. Telomere length was assayed by TRF. (C) CsCl overhang assay showing telomere extension in cells with overexpressed telomerase (top) and inhibitory effect of GRN163L on telomerase action (bottom).
