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. Author manuscript; available in PMC: 2012 May 6.
Published in final edited form as: Mol Cell. 2011 May 6;42(3):297–307. doi: 10.1016/j.molcel.2011.03.020

Figure 4.

Figure 4

Distributive extension of telomere by endogenous telomerase in Hela cells with artificially shortened telomeres. (A) Telomere shortening induced by GRN163L treatment and gradual recovery in length after a removal of drug. (B) Telomerase activity rapidly returns to normal level and remains steady thereafter. (C) CsCl overhang assays of telomerase extension in cells with artificially shortened telomeres 22 PD after release (top). Telomerase action was assayed on CsCl gradients (middle and bottom) in different inhibitory concentrations of GRN163L. See also supplementary Fig. S3.