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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Pharmacol Biochem Behav. 2011 Apr 17;99(1):87–93. doi: 10.1016/j.pbb.2011.04.008

Fig. 5. Adolescent nicotine treatment results in dose-dependent enhanced sensitization to the rearing-increasing effects of nicotine during adulthood.

Fig. 5

The mean (± SEM) rearing counts by adult rats across all 10 test days by rats that received (a) saline during adolescence (and saline, 0.25 mg/kg, or 0.5 mg/kg nicotine in adulthood, n = 6–7/group); (b) 0.25 mg/kg nicotine during adolescence (amd saline, 0.25 mg/kg, or 0.5 mg/kg nicotine in adulthood, n = 6–8/group), or (c) 0.5 mg/kg nicotine during adolescence (and saline, 0.25 mg/kg, or 0.5 mg/kg nicotine in adulthood, n = 6–8/group). Symbols and legend indicate treatment administered during the adulthood 10-day locomotor activity tests. * Indicates that the 0.5 mg/kg nicotine adult-treated group was significantly (p < 0.05) different than saline. + Indicates that the 0.25 mg/kg and 0.5 mg/kg nicotine adult-treated groups were significantly different than saline. # Indicates that all three groups are different from each other.