. 2011 Mar 3;4:7–14. doi: 10.2147/CCID.S10171

Table 3.

Randomized controlled trials showing the effect of pentoxifylline on ulcer healing

Author	Number randomized	Interventions	Outcome measures	Results
Colgan et al⁴⁰	80	All had 2-layer compression Gp1: 400 mg tds pentoxifylline Gp2: placebo	Healing at 24 weeks	Gp1: 60% healed Gp2: 29% healed
Barbarino⁴¹	12	All had 2-layer compression Gp1: 400 mg tds pentoxifylline Gp2: placebo	Healing	Gp1: 66% healed Gp2: 17% healed
Dale et al⁴²	200	All had compression Gp1:400 mg tds pentoxifylline Gp2: placebo	Healing at 24 weeks	Gp1: 64% healed Gp2: 52% healed
Falanga et al⁴³	129	All had compression Gp1: 800 mg tds pentoxifylline Gp2: 400 mg tds pentoxifylline Gp3: placebo	Healing at 24 weeks	Gp1: 73% healed Gp2: 75% healed Gp3: 63% healed
Belcaro et al⁴⁴	172	All had 2-layer compression Gp1: 400 mg tds pentoxifylline Gp2: placebo	Healing and reduction in ulcer size	Gp1: 65% healed, 87% size reduction Gp2: 27% healed, 47% size reduction
Nikolovska et al⁴⁵	80	All had hydrocolloid dressing One group had 400 mg tds pentoxifylline	Healing at 24 weeks	58% healed in pentoxifylline group and 28% in no tablet group

Abbreviations: Gp1, group 1; Gp2, group 2; Gp3, group 3.