Table 4.
Randomized controlled trials showing the effect of different types of skin grafting on ulcer healing
| Author | Number randomized | Interventions | Outcome measures | Results |
|---|---|---|---|---|
| Poskitt et al47 | 53 | Both groups received compression Gp1: pinch skin grafts Gp2: porcine dermis |
Healing at 6 and 12 weeks | Gp1: 64% healed at 6 weeks and 72% at 12 weeks Gp2: 29% healed at 6 weeks and 46% healed at 12 weeks |
| Mol et al48 | 11 | Gp1: human skin equivalents Gp2: punch grafts |
Healing at 20 days | Gp1: 80% healed Gp2: 71% healed |
| Teepe et al49 | 47 | Both groups received short-stretch bandages Gp1: cryopreserved allografts Gp2: controls |
Healing at 6 weeks | Gp1: 25% healed Gp2: 22% healed |
| Warburg et al50 | 31 | Both groups received compression Gp1: meshed split-skin graft Gp2: surgery for incompetent perforators | Healing at 12 months | Gp1: 33% healed Gp2: 38% healed |
| Falanga et al51 | 309 | All received compression Gp1: human skin equivalent Gp2: dressing |
Healing at 6 months | Gp1: 63% healed Gp2: 49% healed |
| Lindgren et al52 | 27 | Both groups received compression Gp1: cryopreserved allografts Gp2: no graft |
Healing at 8 weeks | Gp1: 13% healed Gp2: 17% healed |
| Tausche et al53 | 92 | Gp1: autologous epidermal equivalents derived from hair follicles Gp2: meshed skin autograft | Healing at 6 months | Gp1: 42% healed Gp2: 34% healed |
| Krishnamoorthy et al54 | 53 | All received 4-layer compression Gp1: Dermagraft, weekly for 12 applications Gp2: Dermagraft at 0, 1, 4, and 8 weeks Gp3: Dermagraft at 0 weeks Gp4: No Dermagraft |
Healing at 12 weeks | Gp1: 38% healed Gp2: 38% healed Gp3: 7% healed Gp4: 15% healed |
| Liu et al55 | 10 | Both groups had ulcers debrided and multilayer compression bandaging Gp1: keratinocytes cultured on porcine gelatin microbeads Gp2: keratinocytes cultured on porcine collagen pads |
Healing at 12 weeks | 25% healed in both groups |
| Navrátilová et al56 | 50 | Gp1: cryopreserved cultured epidermal keratinocytes Gp2: lyophilized cultured epidermal keratinocytes |
Healing at 90 days | Gp1: 84% healed Gp2: 80% healed |
| Omar et al57 | 18 | Both groups received 4-layer bandaging Gp1: Dermagraft Gp2: no graft | Healing at 12 weeks | Gp1: 50% healed Gp2: 13% healed |
Abbreviations: Gp1, group 1; Gp2, group 2; Gp3, group 3; Gp4, group 4.