Table 1.
Comparison between myristoylation and palmitoylation
| N-myristoylation | S-palmitoylation | |
|---|---|---|
| Modifying group; | myristate | palmitate |
| Chemical structure; | 14-carbon saturated fatty acid | 16-carbon saturated fatty acid |
| Modification enzyme; | N-myristoyl transferase | dependent on each case |
| Timing; | co-translational | post-translational |
| Linkage; | Gly | Cys |
| Chemical bond; | amide | thio-ester |
| Modified proteins; | Src family members | G protein coupled receptors |
| α subunits of G proteins | HLA | |
| HIV Nef | caveolin | |
| Calcineurin B | CD4 | |
| recoverin | influenza HA | |
| catalytic subunit of A kinase | GAP43 | |
| cytochrome b5 reductase | H-Ras, N-Ras | |
| NAP22 | α subunits of G proteins | |
| MARCKS | Src family members |