Table 1.
Comparison of biochemical parameters in different groups (n = 6)
| Scr (μmol/L) | BUN (mg/dL) | Ccr (mL/min/100 g BW) | K (mmol/L) | Na (mmol/L) | ALD (pmol/L) | Ang II (pmol/L) | |
|---|---|---|---|---|---|---|---|
| CR | 47 ± 6 | 34.2 ± 2.8 | 0.57 ± 0.17 | 4.51 ± 0.32 | 136 ± 5 | 36.4 ± 9.7 | 399.7 ± 100.9 |
| ARR | 69 ± 8 | 40.3 ± 1.2 | 0.45 ± 0.12 | 3.87 ± 0.33* | 146 ± 8 * | 234.6 ± 35.6* | 56.5 ± 10.8* |
| A/ERR | 56 ± 7 | 35.5 ± 3.1 | 0.56 ± 0.13 | 4.61 ± 0.51** | 135 ± 5** | 227.4 ± 27.0* | 51.4 ± 6.2* |
| A/ARR | 62 ± 11 | 38.8 ± 2.1 | 0.46 ± 0.16 | 3.91 ± 0.41* | 141 ± 6* | 233.2 ± 28.8* | 66.4 ± 13.0* |
| A/TRR | 61 ± 8 | 36.5 ± 1.9 | 0.50 ± 0.11 | 3.85 ± 0.38* | 143 ± 8* | 241.8 ± 21.6* | 516.2 ± 77.8*,** |
Values represent group mean ± SEM.
Scr, serum plasma creatinine; BUN, blood urea nitrogen; Ccr, creatinine clearance; K, serum potassium; Na, serum natrium; ALD, plasma aldosterone; Ang II, plasma angiotensin; CR, vehicle-treated; ARR, aldosterone-infused; A/ERR, A/ARR and A/TRR: eplerenone-, amlodipine- and telmisartan-treated.
*
P < 0.01 vs. CR.
**
P < 0.01 vs. ARR.