Table 4.
Association of estimated haplotypes in resistin with inflammatory and metabolic variable and coronary artery calcification
| AGC | AGT | GGT | |
|---|---|---|---|
| Inflammatory markers | |||
| Resistin | 1·06 (0·97–1·16) | 1·02 (0·94–1·11) | 1·06 (0·98–1·15) |
| Soluble TNF receptor 2 | 1·01 (0·96–1·06) | 0·98 (0·93–1·03) | 1·05 (1·00–1·10) |
| Interleukin-6 | 1·02 (0·89–1·16) | 1·03 (0·91–1·16) | 0·95 (0·84–1·06) |
| C-reactive protein | 1·02 (0·83–1·26) | 1·23 (1·01–1·49) | 0·99 (0·82–1·19) |
| Metabolic variables | |||
| Body mass index | 1·00 (0·97–1·04) | 1·00 (0·98–1·03) | 0·99 (0·96–1·02) |
| Triglycerides | 0·97 (0·90–1·05) | 0·97 (0·91–1·05) | 1·03 (0·96–1·11) |
| HDL cholesterol | 1·00 (0·96–1·04) | 0·99 (0·96–1·03) | 0·98 (0·95–1·02) |
| Leptin | 1·01 (0·89–1·14) | 0·95 (0·85–1·07) | 0·94 (0·84–1·05) |
| Adiponectin | 1·09 (0·99–1·20) | 0·99 (0·91–1·09) | 0·97 (0·89–1·06) |
| Metabolic syndrome† | 0·96 (0·59–1·57) | 1·14 (0·72–1·79) | 1·01 (0·64–1·60) |
| Coronary artery calcium‡ | 0·78 (0·55–1·11) | 0·94 (0·68–1·29) | 1·05 (0·77–1·44) |
HDL, high density lipoprotein; TNF, tumour necrosis factor; CI, confidence interval.
The results are presented as the fold change (or the odds ratio for a logistic regression model) and the 95% CI in each outcome for variant resistin haplotype relative to the referent most common haplotype (ACC) in multivariate models, which include age and gender, tobacco and alcohol use, aspirin/statin/niacin use, family history and, when not part of the model outcome, body mass index, metabolic syndrome and Framingham risk score.
Log-transformed continuous variables were used as outcomes in linear regression models.
The presence or absence of National Cholesterol Education Program (NCEP)-defined metabolic syndrome was used as outcome in logistic regression models.
Coronary artery calcium expressed as the natural log of (CAC + 1) was used in linear regression models.
Numbers in bold signify statistically significant values.