Table I.
Summary of genotype data by race/ethnicity.
| EL
|
Count
|
Total | |||||
|---|---|---|---|---|---|---|---|
| rs12970066 | Asn396Ser | rs3829632 (−1309A/G) | White | Black | Hispanic | ||
| 1 | AA | CC | AA | 92 | 64 | 23 | 179 |
| 2 | AA | CC | AG | 5 | 1 | 0 | 6 |
| 3 | AA | CG | AA | 90 | 42 | 24 | 156 |
| 4 | AA | CG | AG | 4 | 1 | 0 | 5* |
| 5 | AA | GG | AA | 35 | 5 | 4 | 44 |
| 6 | AA | GG | AG | 1 | 0 | 0 | 1 |
| 7 | AG | CC | AA | 85 | 6 | 31 | 122 |
| 8 | AG | CC | AG | 2 | 0 | 0 | 2* |
| 9 | AG | CG | AA | 51 | 1 | 13 | 65* |
| 10 | GG | CC | AA | 6 | 0 | 14 | 20 |
| Total | 371 | 120 | 109 | 600 | |||
| ApoE
|
Count
|
Total | ||||
|---|---|---|---|---|---|---|
| Arg112Cys (rs429358) | Arg158Cys (rs7412) | White | Black | Hispanic | ||
| 1 | CC | CC | 6 | 4 | 0 | 10 |
| 2 | CT | CC | 85 | 40 | 31 | 156 |
| 3 | CT | CT | 11 | 2 | 0 | 13* |
| 4 | TT | CC | 221 | 56 | 70 | 347 |
| 5 | TT | CT | 45 | 15 | 8 | 68 |
| Total | 368 | 117 | 109 | 594 | ||
*
Haplotypic phase is unobservable for individuals with the corresponding genotype. A total of 56 genotypes are observed within HL across the three racial/ethnic groups (38 observed genotypes in Whites, 33 in Black/non-Hispanics and 34 in Hispanics), and 52 genotypes are observed for ApoCIII (43 observed genotypes in Whites, 24 in Black/non-Hispanics and 25 in Hispanics). 595 individuals have complete genotype data for HL, and 595 individuals have complete genotype data for ApoCIII. Haplotypic phase is unobservable in 43.4 and 60.8 per cent of our cohort for HL and ApoCIII, respectively.