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. 2010 Oct 18;9(12):6759–6773. doi: 10.1021/pr1009178

Table 1. Treg-Induced HIV-1/VSV BMM Proteins Identified After Strict Filtering of iTRAQ Dataa.

name of protein NCBI accession number M.W. [kDa] 117/115b P-valuec function
Granzyme A 6754102 28.6 2.1574 0.0040 Induces apoptosis of pathogen infected cells
Granzyme B 7305123 27.5 4.0877 0.0000 Induces apoptosis of pathogen infected cells
Granzyme D 3334466 27.6 3.9000 0.0000 Induces apoptosis of pathogen infected cells
ISG15 ubiquitin-like modifier 80476034 17.9 1.6406 0.0024 Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. May also be involved in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing IFN-gamma secretion by monocytes and macrophages. Seems to display antiviral activity during viral infections
Interferon-induced guanylate-binding protein 2 37999845 66.7 2.6956 0.0000 IFN immune response. Binds GTP, GDP and GMP.
Guanylate-binding protein 5 37999681 66.9 2.2865 0.0039 IFN immune response
Interferon-inducible GTPase 1 88909159 47.6 1.9876 0.0139 May play a role in resistance to intracellular pathogens. Has low GTPase activity. Has higher affinity for GDP than for GTP.
Immune-responsive gene 1 protein 119364598 53.8 1.9306 0.0262 Immune response - IFN-inducible gene
Tryptophanyl-tRNA synthetase, cytoplasmic 51704226 54.4 1.1543 0.0117 IFN-gamma induced protein. Protein synthesis
Prolow-density lipoprotein receptor-related protein 1 81867523 504.7 0.7061 0.0077 Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis.
Twinfilin-1 92090648 40.1 0.9064 0.0040 Actin-binding protein involved in motile and morphological processes
Sialic acid binding Ig-like lectin 1, sialoadhesin 187954777 183.1 0.8250 0.0186 Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes.
Pyruvate dehydrogenase (lipoamide) beta 63101525 38.9 0.8850 0.0276 Metabolism
a

Protein quantitation was made using iTRAQ as performed on cell lysates of BMM from three separate experiments.

b

These experiments compared HIV-1/VSV infected murine BMM that were cocultured with murine Treg (117 label) to HIV-1/VSV infected murine BMM cultured alone (115 label).

c

P-value after Benjamini and Hochberg FDR adjustment.