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Mechanisms which trigger pulmonary arterial hypertension (PAH) as targets for pharmacological treatments. cAMP, cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; ET, endothelin; ETA, endothelin receptor A; ETB, endothelin receptor B; PDE5, phosphodiesterase type-5; PgI2, prostaglandin I2. Reproduced with permission from Humbert et al. (2004a) and Boutet et al. (2008).
