Table 2.
Residues presumably involved in binding different IKM activators.
| Drugs | Binding site | Reference |
|---|---|---|
| R198 (S4), L200 (S4), R207 (S4), and R214 (S4)Retigabine | W236 (S5), L243 (S5), L275 (pore), L299 (S6 of the neighboring subunit), and G301 (S6) | Wuttke et al. (2005), Schenzer et al. (2005), Lange et al. (2009) |
| Zinc pyrithione | L249 (S5), L275 (pore), and A306 (S6) | Xiong et al. (2007) |
| Diphenylamine carboxylate derivate NH29 | K120 (loop S1–S2), Y127 (S2), E130 (S2), L197 (S4), R198 (S4), L200 (S4), R207 (S4), and R214 (S4) | Peretz et al. (2010) |
| ICA-27243 | S1-S4 transmembrane domain | Padilla et al. (2009) |
| Acrylamide derivate (S)-1 | W242 (S5; according to Kv7.4 numbering) | Bentzen et al. (2006) |
| BMS-204354 | W242 (S5; according to Kv7.4 numbering) | Bentzen et al. (2006) |
| NEM (N-ethylmaleimide) | C242 (S5); C519 (C-terminal; according to Kv7.4 numbering) | Li et al. (2004), Roche et al. (2002) |
| H2O2 | C150 to C153 | Gamper et al. (2006) |