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Overexpression of SOD2 in astrocytes reduces vulnerability of CA1 neurons. GFAPp-SOD2 or control DNA was injected unilaterally above the hippocampus two days prior to forebrain ischemia. A: Cresyl violet stained brain sections show that selective CA1 hippocampal neuronal loss is significantly lower in GFAPp-SOD2 injected brain than in control seven days after forebrain ischemia. B: Quantitation of cresyl violet staining showed significant preservation of CA1 neurons (n = 3; P < 0.05).
