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. Author manuscript; available in PMC: 2011 Jun 6.
Published in final edited form as: Nat Biotechnol. 2008 Jun;26(6):659–667. doi: 10.1038/nbt1401

Figure 4. Summary of the in silico methods utilized in published E. coli GEM studies.

Figure 4

This heatmap characterizes the incorporation of different computational methods into studies utilizing genome-scale models of E. coli. A dark box indicates that a particular method (one method per row) was utilized in a corresponding study (one citation per column); the frequency of usage of a particular method is given on the right. Studies were grouped into one of five general categories and studies examining phenotypic behavior were further divided into three subgroups. Studies that contributed new experimental growth data are also marked along the bottom offset row.