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. Author manuscript; available in PMC: 2012 Apr 6.
Published in final edited form as: Cell Metab. 2011 Apr 6;13(4):450–460. doi: 10.1016/j.cmet.2011.03.013

Fig.5. PARP-2−/− mice are protected against diet-induced body weight gain and insulin resistance.

Fig.5

(A) 6 month old PARP-2+/+ and −/− male mice (n= 7 and 9, respectively) fed on high fat diet were weighed weekly (B) Food intake was monitored during high-fat feeding. (C) Body fat mass composition was evaluated through EchoMRI. (D) The weight of the tissues indicated was determined upon autopsy at the end of the high-fat feeding period. (E) VO2 and (F) spontaneous activity was determined by indirect calorimetry. Quantification of the mean values during light and dark phases are shown. (G) mRNA expression levels in gastrocnemius muscles from PARP-2+/+ and −/− mice after 12 weeks of high-fat diet was determined by qRT-PCR (H) Glucose excursion after an intraperitoneal insulin tolerance test. White bars and circles represent PARP-2+/+ mice, while black bars and circles represent PARP-2−/− mice. * indicates statistical difference vs. PARP-2+/+ mice at p<0.05