Table 3.
Case reports and small series of inflammatory bowel disease outcomes after myeloablation and allogeneic stem cell transplantation
| Disease (n) | Indication | Conditioning | Graft | IBD outcome | Ref |
|---|---|---|---|---|---|
| UC (n = 1) | AML | Not stated | Not stated | Remission 4 yrs | 20 |
| CD (n = 1) | AML | Chemo | AlloBMT CSA for 7 mos | Remission 7 years off immunosuppression | 22 |
| Steroids for 2 mos | |||||
| CD (n = 5) | CML | Chemo TBI | AlloBMT, varied | Remission in 4 of 5 patients followed for 4–15 yrs | 23 |
| (A sixth CD patient with AML died 97 days after alloBMT; recurrent CD could not be evaluated) | |||||
| CD (n = 7) UC (n = 4) |
AML, CML, MF | Varied | AlloBMT, varied | Remission in 9 of 10 survivors | 24 |
| CD (n = 1) | IBD, IL-10RB mutation | Chemo | Sibling AlloBMT | Remission 1 yr | 4 |
Abbreviations: See list in text.