Table 3.
Oral use of aspirin or NSAIDs, drugs which may be related to bleeding, alcohol, tobacco, and Helicobacter pylori
|
1985–1986 |
1995–1996 |
2007–2008 |
Pvalue | |
|---|---|---|---|---|
| n = 99 | n = 108 | n = 99 | ||
| High-dose aspirin1 | 18 (18)a | 8 (7)b | 1 (1)c | 0.0001 (a vs c) |
| Low-dose aspirin2 | 1 (1)a | 12 (11)b | 37 (37)c | 0.007–0.0000 |
| NSAIDs3 | 12 (12)a | 24 (22)b | 42 (42)c | 0.03–0.0003 (a, b, vs c) |
| Aspirin or NSAIDs | 31 (31)a | 42 (39)b | 66 (67)c | 0.004–0.03 (a, b, vs c) |
| Aspirin or NSAIDs | ||||
| 20–75years | 20/66 (30)a | 22/69 (32)b | 22/36 (61)c | 0.06 (a vs c) |
| > 75 years | 11/33 (33)a | 20/39 (51)b | 44/63 (70)c | 0.06 (a vs c) |
| Warfarin | 0a | 4 (4)b | 18 (18)c | 0.0000–0.002 (a, b vs c) |
| Steroids | 1 (1)a | 9 (8)b | 12 (12)c | 0.02–0.003 (a vs b, c) |
| Alcohol | 8 (8) | 6 (6) | 7 (7) | NS |
| Tobacco | 27 (27) | 21 (19) | 15 (15) | NS |
| H. pylori tested | 87 (81) | 75 (76) | NS | |
| H. pylori positive | 73 (84) | 39 (52) | 0.06 | |
| H. pylori positive | ||||
| Duodenal ulcer | 51/62 (82) | 27/47 (57) | NS | |
| Gastric ulcer | 22/25 (88) | 12/28 (43) | NS | |
| H. pylori positive | ||||
| Aspirin or NSAID users | 22/30 (73) | 28/55 (51) | NS | |
| Nonusers | 51/57 (89) | 11/20 (55) | NS |
Notes:
1
Aspirin 0.5–1g;
2
Aspirin 75–160 mg;
1,2,3
Patients with simultaneous use of aspirin and NSAID are recorded twice.
Abbreviations: NS, not significant; NSAID, nonsteroidal anti-inflammatory drug.