Table 2.
Phase 1 | Phase 2 | Phase 3 | |
---|---|---|---|
Serotonin or dopamine transporter entrance gates | Partially closed | Open | Open |
Transporter lumen saturation | Unsaturated | Unsaturated | Saturated |
Note:
In Phase 1, the serotonin and dopamine gates are partially closed, restricting access to the transporter. In Phases 2 and 3, the gates are open, allowing full access to the transporter by serotonin and dopamine. In Phases 1 and 2, the lumen of the transporter is not saturated with serotonin and dopamine. In Phase 3, the lumen of the transporter is saturated with serotonin or dopamine.5