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Farnesyl pyrophosphate synthase enzyme inhibition potency (IC50) of nitrogen-containing bisphosphonates (inhibition of 50% of maximum enzyme activity). Note that zoledronic acid shows the higher affinity for the mineral matrix combined with the higher inhibition potency of farnesyl pyrophosphate synthase.26
Abbreviations: ALN, alendronate; IBN, ibandronate; RIS, risendronate; ZOL, zolendronic acid.
