. 2010 Sep 28;2:181–189. doi: 10.2147/DHPS.S13225

Table 1.

Studies in which suicidality potential of specific antiepileptic drugs (AEDs) was investigated

Study	Specific antiepileptic drugs and main published statistical findings
FDA – Levenson 200853	Lamotrigine	2.08 (1.03–4.40)
N = 199 clinical trials involving AEDs	Topiramate	2.53 (1.21–5.85)
N = 199 clinical trials involving AEDs	All other AEDs	No significant risk
Oleson 201057	All AEDs at initiation	1.84 (1.36–2.49)
All patients prescribed AEDs during study pd., all diagnoses	Clonazepam	2.01 (1.25–3.25)
	Valproate	2.08 (1.04–4.16)
	Lamotrigine	3.15 (1.35–7.34)
	Phenobarbital	1.96 (1.02–3.25)
Patorno 201058	Gabapentin	1.42 (1.11–1.80)
All patients initiated with AED therapy; using suicide rate with topiramate as reference	Lamotrigine	1.84 (1.43–2.37)
	Oxcarbazepine	2.07 (1.56–2.80)
	Tiagabine	2.41 (1.65–3.52)
	Valproate	1.65 (1.25–2.19)
Gibbons 201059	AED therapy	13 suicides per 1000 pt-yrs
Bipolar affective disorder population	No AED therapy	13 suicides per 1000 pt-yrs
Bipolar affective disorder population		No significant difference
van Cott 201060	Prior dx affective disorder	4.2 (2.4–7.5)
Suicide rates in all pts starting AED therapy, any indication vs epilepsy	AED indication: epil vs other	No significant difference
	Lamotrigine & levetiracetam	10.2 (1.1–97.0)
	Valproate	2.3 (1.0–5.3)
	Phenobarbital, phenytoin, carbamazepine	No significant difference
Andersohn 201061	“High” depressive potential^*	3.08 (1.22–7.77)
Epilepsy cohort, those with suicidality vs no diagnosis of suicidality	“Low” depressive potential^*	0.87 (0.47–1.59)
	Conventional AEDs	0.74 (0.53–1.03)
	Barbiturates	0.66 (0.25–1.73)

Notes: First author, abbreviated summary of study design, and main published statistical findings are shown.

* = See text for definition of AEDs defined as having “high” and “low” depressive potential. Results displayed are Odd’s ratio + 95% confidence intervals except where otherwise indicated.