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| Drug | Bioavailability (%) | Time to peak onset (hours) | Metabolism (metabolite activity) | Half-life (hours) | Elimination | Protein binding (%) |
|---|---|---|---|---|---|---|
| Sildenafil | 41 | 0.5–2 | Hepatic (active) | 4 | Fecal (80%) Renal (13%) |
96 |
| Tadalafil | N/A | 2–8 | Hepatic (inactive) | 15 | Fecal (61%) Renal (36%) |
94 |
| Vardenafil | 15 | 0.5–2 | Hepatic (active) | 4–5 | Fecal (91%–95%) Renal (2%–6%) |
95 |
Abbreviation: N/A, not available.
