Table 1.

Microdilution minimum inhibitory concentration and minimum effective concentration (μg/mL) for the clinically available echinocandins against Candida and Aspergillus species (Tawara et al 2000; Arikan et al 2003; Espinel-Ingroff 2003; Heyn et al 2005; Ostrosky-Zeichner et al 2005; Pfaller et al 2006; Messer et al 2006; Pfaller et al 2006; Pfaller and Diekema 2007; Garcia-Effron et al 2008a)

Species	Micafungin		Anidulafungin		Caspofungin
	MIC range	MIC90range	MIC range	MIC90 range	MIC range	MIC90 range
Candida species
C. albicans	0.01 to ≥8	0.01–0.5	0.01 to ≥8	0.01–0.5	0.01 to ≥8	0.12–1
C. glabrata	0.01 to ≥8	0.01–0.5	0.01–8	0.12–0.5	0.01 to ≥8	0.06–1
C. parapsilosis	0.03 to ≥8	1 to >8	0.01 to ≥8	2 to >8	0.03 to ≥8	1–4
C. tropicalis	0.01 to ≥8	0.03–2	0.03 to ≥8	0.06–2	0.03 to ≥8	0.06–1
C. krusei	0.06–4	0.12–0.25	0.01–8	0.03–1	0.12 to ≥4	0.25– 2
Species	MEC range	MEC90 range	MEC range	MEC90range	MEC range	MEC90 range
Aspergillus species
A. fumigatus	0.007–0.125	0.015–0.125	0.06	0.06	0.06–0.125	0.125
A. terreus	0.004–0.008	0.004–0.008	0.03	0.03	0.125–2	1
A. flavus	0.003–0.125	0.015–0.125	0.03–0.125	0.03–0.125	0.03–0.125	0.125
A. niger	0.007–0.0125	0.008–.125	0.03–0.125	0.06–0.125	0.125–2	0.125–1

Abbreviations: MEC, minimum effective concentration; MIC, minimum inhibitory concentration.