Table 2.
Amino acid sequences and nucleotide changes in susceptible and resistant isolates from various Candida species reported in the literature
| Isolates | Protein sequence | Nucleotide change | Caspofungin MIC (μg/mL) |
|---|---|---|---|
| Candida albicans (Wiederhold et al 2008) | |||
| SC5314 | FLTLSLRDP | – | 0.125 |
| 2762 | SLTLSLRDP | T1922C | 4 |
| 53264 | FLTLPLRDP | T1933C | 4 |
| Candida glabrata (Thompson et al 2008; Cleary et al 2008) | |||
| 7754 | FFLILSLRDP | – | 0.25 |
| 7755 | FVLILSLRDP (Hot Spot 1) | T1975G | 2 |
| 06-3169 | FLILSLREP (Hot Spot 2) | T1896G | >2 |
| Candida krusei (Kahn et al 2007) | |||
| Ck-98 | FLILSIRDP | – | 0.25 |
| Ck-100 | CLILSIRDP | T2080K | 8 |
| Candida tropicalis (Garcia-Effron et al 2008b) | |||
| ATCC 750 | FLTSLRDP | – | 0.25 |
| T3 | FLTLS/PLRDP | T1935C | 4 |
| T26 | LLTLSLRDP | T1923C | 1 |
| Candida parapsilosis (Codon Change) (Garcia-Effron et al 2008a) | |||
| ATCC 22019 | FLTLSLRDA | P660A | 1.4 |
| H4 | FLTSLRDA | P660A | 2.24 |
Note: Bolded and italicized letters refer to amino acid changes within protein sequences as a result of a nucleic acid point mutation.
Abbreviation: MIC, minimum inhibitory concentration.