Table 3.
Secondary resistance mutation patterns associated with Y143CHRK
| Associated secondary mutationsa | Effects on drug resistance or viral fitness of Y143CHRK mutants |
|---|---|
| L74M + T97A40,53 | |
| L74M + T97A + S119T + E138D53 | |
| L74M + T97A + E138A40 | Increases raltegravir resistance compared to addition of T97A alone |
| L74M + E138D78 | |
| T97A40 | Increases raltegravir resistance |
| T97A + E138A40 | |
| T97A + G140D + G163R38 | |
| G140S40 | Increases raltegravir resistance |
| N155H40,77,79 | |
| N155H + E170A79 |
Notes:
a
Shown are mutation patterns found in the same viral sample during in vitro or in vivo selection using raltegravir or elvitegravir. Mutations present at baseline or containing mixtures by population-based sequencing were excluded. References are given for each pattern of resistance mutations.