Table 4.
Other integrase resistance mutation patterns
| Other resistance mutation patternsa | Effects on drug resistance or viral fitness |
|---|---|
| H51Y + E92Q + S147G35 | Increased resistance to elvitegravir compared to E92Q alone |
| G59E33 | |
| T66I/A/K33,56,74,80 | Resistance to elvitegravir; resistance to raltegravir depending on mutation |
| T66I + V72A + A128T33,56 | Resistance to elvitegravir |
| T66A + L74I + E92Q52 | |
| T66I + E92Q + T124A33,56 | Resistance to elvitegravir |
| T66I + Q95K + E138K + Q146P + S147G35 | Increased resistance to elvitegravir compared to addition of T66I + Q146P + S147G |
| T66I/K + T124A33,56 | Resistance to elvitegravir |
| T66I + T124A + Q146L33,56 | Resistance to elvitegravir |
| T66I + Q146P35 | Increased resistance to elvitegravir compared to T66I or Q146P alone |
| T66I + Q146P + S147G35 | Increased resistance to elvitegravir compared to addition of T66I + Q146P |
| T66I + S230R74 | Resistance to elvitegravir |
| L68V/I + E92Q36 | Increased resistance to elvitegravir and raltegravir compared to E92Q alone |
| E92Q33,35,42,49,56,74,80 | Resistance to elvitegravir |
| E92QV + T124A33,56 | Resistance to elvitegravir |
| E92Q + M154I33 | Resistance to raltegravir |
| T124A33,56 | No resistance to raltegravir or elvitegravir |
| T124A + P145S33,56 | Resistance to elvitegravir |
| T124A + Q146L33,56 | Resistance to elvitegravir |
| P145S33,56,81 | Resistance to elvitegravir |
| Q146P + N232D35 | Resistance to elvitegravir |
| V151I33 | Resistance to elvitegravir |
| E157Q49 | |
| S230N/R73,74 | No effect on raltegravir or elvitegravir resistance |
Notes:
a
Shown are mutation patterns found in the same viral sample during in vitro or in vivo selection using raltegravir or elvitegravir. Mutations present at baseline or containing mixtures by population-based sequencing were excluded. References are given for each pattern of resistance mutations.