Table 2.

Antibiotics for the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Antibiotic	Pediatric dose	Adult dose
Oral ciprofloxacin	10–20 mg/kg twice a day	500–750 mg twice a day
Tobramycin via inhalation	300 mg by nebulizer, twice a daya	300 mg by nebulizer, twice a day
Colistin via inhalation	75–150 mg by nebulizer, twice a dayb	75–150 mg by nebulizer, twice a day
Ciprofloxacin	10 mg/kg intravenously every 8–12 h	400 mg intravenously every 12 h
Ceftazidime	50–100 mg/kg intravenously every 8 h	2 g intravenously every 8 h
Cefepime	50 mg/kg intravenously every 8 h	2 g intravenously every 8 h
Piperacillin–tazobactam	90 mg/kg intravenously every 6 h	4.5 g intravenously every 6–8 h
Aztreonam	50 mg/kg intravenously every 8 h	2 g intravenously every 8 h
Imipenem	15–25 mg/kg intravenously every 6 h	500 mg to 1 g intravenously every 6 h
Meropenem	40 mg/kg intravenously every 8 h	1–2 g intravenously every 8 h
Doripenem	10–15 mg/kg intravenously every 8 h	500 mg intravenously every 8 h
Tobramycin	5–10 mg/kg intravenously every 24 hc	7 mg/kg intravenously every 24 hc
Amikacin	20–30 mg/kg intravenously every 24 hd	15–20 mg/kg intravenously every 24 hd
Colistin	1.5–2 mg/kg intravenously every 8 he	80–160 mg intravenously every 8 hf

Notes:

^aIn patients <6 years, inhaled tobramycin, 80 mg/12 h;

^bDose expressed as milligrams of colistimethate; 1 mg of colistimethate = 12,500 IU. The recommended dose of 75–150 mg/12 h is approximately equal to 1–2 million IU, twice a day;

^cDosage should be adjusted to serum trough concentration <1 μg/mL;

^dDosage should be adjusted to serum trough concentration <4–5 μg/mL;

^eDose expressed as milligrams of colistimethate for patients <60 kg. Pediatric dose: 18,000–24,000 IU/kg every 8 h;

^fDose expressed as milligrams of colistimethate for patients ≥60 kg. Adults dose: 1–2 million IU every 8 h.