Fig. 7.

Distribution of FVIII core peptides in four different donors. Different core peptides are presented by different donors. Results displayed in this figure. were obtained from single experiments for all donors. FVIII-derived MHC class II peptides are represented as rectangles for each individual donor. Indicated in yellow are sequences that are common between two donors. Indicated in orange are sequences common between three donors. Indicated in red is a sequence that is common in all four donors. The different domains and the location of the peptides are depicted schematically. Some sequences have been marked with a reference number, indicating that they have been identified previously as CD4⁺ T-cell epitope in the corresponding publication.