Table 3.
Enzyme | Z′ score | Hit rate* | # Hits | Reconfirmed (powders) | Reconfirmation Enzyme (IC50 μM) | 3d7 falciparum (EC50 μM) |
---|---|---|---|---|---|---|
Pf Choline Kinase | 0.802 | 1.2% | 69 | 9 of 23 | 2.9 – 19.0 | 0.04 – 0.7 |
Pf dUTPase | 0.466 | 3.1% | 95 | 0 specific to dUTPase | n/a | n/a |
Pf OMP Decarboxylase | 0.751 | 0.5% | 26 | 4 of 11 | 2.4 – 58.0 | 0.093 – 6.0 |
Pf S-adenosyl-Homocysteine Hydrolase | 0.400 | 0.7% | 38 | 7 of 19 | 0.1 – 9.1 | 0.9 – 7.6 |
Pf Glutamate Dehydrogenase | 0.783 | 2.9% | 164 | 0 of 78 | n/a | n/a |
Pv Guanylate Kinase | 0.571 | 0.3% | 17 | 4 of 7 | 2.9 – 4.0 | 0.092 – 3.4 |
Pf Adenylosuccinate Synthase | 0.667 | 0.2% | 9 | 5 of 6 | 1.7 – 22.9 | 0.2 – 1.6 |
Pf N-Myristoyl Transferase | 0.640 | 0.2% | 6 | 5 of 5 | 1.4 – 8.6 | 0.04 – 2.6 |
Pf Farnesyl Pyrophosphate Synthase | 0.667 | 0.2% | 6 | 0 specific to FPPS | n/a | n/a |
Determined based on size of compound collection screened. See Methods for details.