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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Mol Biochem Parasitol. 2010 Sep 15;175(1):21–29. doi: 10.1016/j.molbiopara.2010.08.005

Table 3.

Results of biochemical screens

Enzyme Z′ score Hit rate* # Hits Reconfirmed (powders) Reconfirmation Enzyme (IC50 μM) 3d7 falciparum (EC50 μM)
Pf Choline Kinase 0.802 1.2% 69 9 of 23 2.9 – 19.0 0.04 – 0.7
Pf dUTPase 0.466 3.1% 95 0 specific to dUTPase n/a n/a
Pf OMP Decarboxylase 0.751 0.5% 26 4 of 11 2.4 – 58.0 0.093 – 6.0
Pf S-adenosyl-Homocysteine Hydrolase 0.400 0.7% 38 7 of 19 0.1 – 9.1 0.9 – 7.6
Pf Glutamate Dehydrogenase 0.783 2.9% 164 0 of 78 n/a n/a
Pv Guanylate Kinase 0.571 0.3% 17 4 of 7 2.9 – 4.0 0.092 – 3.4
Pf Adenylosuccinate Synthase 0.667 0.2% 9 5 of 6 1.7 – 22.9 0.2 – 1.6
Pf N-Myristoyl Transferase 0.640 0.2% 6 5 of 5 1.4 – 8.6 0.04 – 2.6
Pf Farnesyl Pyrophosphate Synthase 0.667 0.2% 6 0 specific to FPPS n/a n/a
*

Determined based on size of compound collection screened. See Methods for details.