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. Author manuscript; available in PMC: 2012 May 25.
Published in final edited form as: J Am Chem Soc. 2011 May 3;133(20):7700–7703. doi: 10.1021/ja2023898

Scheme 4.

Scheme 4

Synthesis of large constrained peptides.a

aKey: (a) PPh3, THF, H2O. (b) Boc–Lys–Gly–CO2H, HATU, DIPEA, DMF. (c) Pd/C, MeOH, H2. (d) HCl·H2N–Gly–Ala–OBn, HATU, DIPEA, DMF. (e) 10% Pd/C, MeOH, H2. (f) TFA, CH2Cl2.