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. Author manuscript; available in PMC: 2012 May 25.
Published in final edited form as: J Am Chem Soc. 2011 May 3;133(20):7700–7703. doi: 10.1021/ja2023898

Table 3.

Synthesis of constrained tripeptides.a

graphic file with name nihms294143u4.jpg
Entry Bis N–formyl tripeptide Constrained peptide Yield
1 graphic file with name nihms294143t20.jpg
17 		graphic file with name nihms294143t21.jpg
28 		60%
2 graphic file with name nihms294143t22.jpg
21 		graphic file with name nihms294143t23.jpg
29 		55%
3 graphic file with name nihms294143t24.jpg
23 		graphic file with name nihms294143t25.jpg
30 		53%
4 graphic file with name nihms294143t26.jpg
24 		graphic file with name nihms294143t27.jpg
31 		45%
a

Key: (a) LiBH4, CH2Cl2, n-PrOH, Ac2O, −60 °C. (b) TFA, CH2Cl2.