Figure 3.

Human chromosomal regions implicated in hypertension based on rat–human comparative maps for 67 QTLs identified in seven different progenies from genetically hypertensive rats. Distribution of the 26 predicted genomic regions in the human genome located on 16 different autosomes based on cytogenetics. Human chromosomes 6, 12, 14, 20, 21, and 22 do not contain positional candidate loci predicted by the rat studies, and the sex chromosomes were not evaluated in this study. Regions of the genome in which multiple blood pressure-related phenotypes cluster from more than one cross are designated first priority regions. There are 20 of 26 regions that fall into this category (boxed regions). We predict six “second priority regions” based on QTLs identified in a single rat cross that may represent either areas of interest for a distinct subtype of hypertension or areas harboring modifier genes for blood pressure (nonboxed regions). Confidence level for placement of syntenic regions designated by vertical bars: (Red) Highest, (blue) high, (black) moderate. Numbers: (Black) SHR × BN, (purple) SS/MCW × BN, (blue) SHR × WKY, (red) SHR × DRY, (dark green) ACI × FHH, (light green) GH × BN, (magenta) LH × LN. Mouse syntenic QTLs are represented by the vertical bars to the left of the human idiograms. (Star) Genomic region reported with significant or suggestive linkage in genome scans for hypertension in humans.