Table 1. Association of MBP locus with rheumatoid arthritis in the Japanese population.
Chr | dbSNPID | Gene | Allele | DNA Collection | Genotype counts | Success rate | HWEp | RAF** | p-value | OR | mhp *** | |||
Ref.(A1)/Var.(A2) | A1A1 | A1A2 | A2A2 | (95%CI) | ||||||||||
18q23 | rs2000811 | MBP | C/T* | 1 | case | 203 | 303 | 136 | 99.8 | 0.25 | 0.45 | 0.0036 | 1.25 | |
control | 344 | 442 | 148 | 100 | 0.76 | 0.4 | (1.08–1.44) | |||||||
2 | case | 95 | 152 | 79 | 99.7 | 0.24 | 0.48 | 5.7×10−4 | 1.49 | |||||
control | 120 | 131 | 46 | 100 | 0.31 | 0.38 | (1.19–1.87) | |||||||
3 | case | 283 | 392 | 182 | 98.1 | 0.034 | 0.44 | 0.023 | 1.17 | |||||
control | 298 | 404 | 134 | 97.8 | 0.88 | 0.4 | (1.02–1.34) | |||||||
4 | case | 393 | 622 | 233 | 98.7 | 0.63 | 0.44 | 0.0041 | 1.19 | |||||
control | 341 | 451 | 141 | 98.4 | 0.68 | 0.39 | (1.06–1.35) | |||||||
3+4 | case | 676 | 1014 | 415 | 98.5 | 0.32 | 0.44 | 3.0×10−4 | 1.18 | |||||
control | 639 | 855 | 275 | 98.1 | 0.69 | 0.4 | (1.08–1.30) | |||||||
pooled | case | 974 | 1469 | 630 | 98.9 | 0.078 | 0.44 | 4.0×10−8 | 1.23 | 2.7×10−8 | ||||
control | 1103 | 1428 | 469 | 98.9 | 0.85 | 0.39 | (1.14–1.32) |
*risk allele for the disease,
**risk allele frequency, and
***p-value in meta-analysis using Cochran-Mantel-Haenszel test.