Table 1.
Results of leave-one-out cross-validation experiments on the small network.
| Random Control (%) | Linkage Interval (%) | Genome-wide Scan(%) | |||||
|---|---|---|---|---|---|---|---|
| R2 | BF | R2 | BF | R2 | BF | ||
| Precision | SG | 26.11 (0.66) | 26.56 (0.85) | 21.69 | 23.79 | 6.29 | 5.25 |
| DK | 26.25 (0.63) | 28.67 (0.72) | 19.60 | 31.20 | 7.13 | 5.53 | |
| Mean Rank Ratio | SG | 17.31 (0.11) | 11.99 (0.05) | 18.24 | 11.19 | 16.49 | 11.17 |
| DK | 17.82 (0.13) | 10.75 (0.09) | 19.09 | 9.73 | 17.03 | 9.91 | |
| AUC | SG | 83.51 (0.10) | 88.80 (0.05) | 82.81 | 89.94 | 83.60 | 88.85 |
| DK | 83.01 (0.12) | 90.04 (0.11) | 81.95 | 90.18 | 83.06 | 90.11 | |
The small network indicates the domain-domain interaction network that is composed of the PDB part of the DOMINE database. R2 denotes the ordinary non-Bayesian linear regression approach (using R-square as scores for candidate domains). BF denotes the domainRBF approach (using Bayes factors as scores for candidate domains). SG denotes shortest path with Gaussian kernel. DK denotes diffusion kernel. Results for random controls are mean (standard deviation) of 10 validation runs.