Table 4.
Effects of seed domain-disease associations based on leave-one-out cross-validation experiments.
| Criteria | Cutoff | Random Control (%) | Linkage Interval (%) | Genome-wide Scan (%) |
|---|---|---|---|---|
| Precision | 90% | 28.28 (0.42) | 33.45 (1.57) | 5.34 (0.33) |
| 80% | 27.42 (0.76) | 32.06 (1.44) | 4.79 (0.47) | |
| 70% | 27.43 (1.06) | 29.59 (0.93) | 3.97 (0.74) | |
| 60% | 25.68 (1.04) | 30.11 (1.10) | 3.58 (0.58) | |
| 50% | 25.85 (0.73) | 28.47 (0.89) | 5.35 (1.22) | |
| Mean Rank Ratio | 90% | 10.90 (0.78) | 8.98 (0.64) | 10.16 (0.81) |
| 80% | 11.23 (0.84) | 9.37 (0.92) | 10.38 (1.02) | |
| 70% | 11.68 (1.21) | 10.09 (1.05) | 10.61 (0.69) | |
| 60% | 12.37 (0.97) | 9.21 (1.01) | 10.76 (0.80) | |
| 50% | 13.47 (0.55) | 9.72 (0.98) | 10.95 (0.78) | |
| AUC | 90% | 89.92 (0.30) | 90.83 (0.58) | 89.87 (0.61) |
| 80% | 89.60 (0.22) | 90.26 (0.43) | 89.66 (0.29) | |
| 70% | 89.15 (0.17) | 89.40 (0.64) | 89.46 (0.48) | |
| 60% | 88.48 (0.59) | 90.01 (0.51) | 89.32 (0.34) | |
| 50% | 87.31 (0.28) | 89.89 (0.46) | 89.16 (0.75) | |
The small domain-domain interaction network composed of the PDB part of the DOMINE database and the diffusion kernel are used to obtain the results. Results for random controls are mean (standard deviation) of 10 validation runs.