Figure 6. Enrichment of highly down-regulated mRNAs for miR-K12-11 target predictions.

As in Figure 4, the enrichment of bona fide targets within gene sets of increasing size, ordered by increasing model score, is shown. A 6-in-8 filter was used for model training and prediction (cf. Figure 4B). Different observed mRNA log₂ fold change values (−0.5, and −0.6) were used as a cutoff for bona fide targets. The corresponding baseline enrichments resulting from 6-mer seed matches are also shown.