Figure 6. Dynamic analysis of cytoadherence features of eight isolates during the adaptive cultivation.

Significant binding was defined as >5PRBC/mm2, and the final value of bound cells numbers was adjusted in terms of parasitemia of different batches used in the assay. The four purified receptors, CD36, ICAM-1, CSA, and HA were used as immobilized receptors with BSA as negative control. The time points of upregulation of ICAM-1 binding activity were indicated by arrows.