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. 2011 Jun 6;6(6):e20703. doi: 10.1371/journal.pone.0020703

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Lurie et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Forest plot of the ORs and 95% CIs for invasive ovarian carcinoma risk associated with carriage of the ESR2 rs1271572 TT genotype versus GG/GT genotypes (recessive genetic model) in subgroups of women ≤50 (A) versus > 50 years (B) of age. Pooled^a OR for all studies combined among women ≤50 years was 1.35 (95% CI: 1.12–1.62; p = 0.002); p for heterogeneity among studies = 0.19. Pooled^b OR for all studies excluding HAW was 1.34 (95% CI: 1.11–1.61; p = 0.009); p for heterogeneity among studies = 0.29. P for interaction between ESR2 rs1271572 and age = 0.02.