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. 2011 Jun 6;6(6):e20863. doi: 10.1371/journal.pone.0020863

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Fernández-Velasco et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Activation kinetics of I_Ca over the whole voltage range were not significantly different between WT (open symbols) and CPVT (filled symbols) cells. B. The time course of inactivation of I_Ca, which encompass slow and fast components, were similar in WT and CPVT cells at all voltages studied. C. Superimposed voltage-dependence of I_Ca activation and inactivation. I_Ca activationis shifted to more positive values in CPVT vs WT cells, whereas inactivation of I_Ca is shifted to more hyperpolarized potential in CPVT cells compared with WT cells. D. Voltage dependence of I_Ca window current () display a bell-shaped voltage-dependence, however, the peak of is reduced in CPVT cells (continuous line) compared to WT cells (dashed line). * P<0.05 and ** P<0.005.

Inline graphic — A. Activation kinetics of I_Ca over the whole voltage range were not significantly different between WT (open symbols) and CPVT (filled symbols) cells. B. The time course of inactivation of I_Ca, which encompass slow and fast components, were similar in WT and CPVT cells at all voltages studied. C. Superimposed voltage-dependence of I_Ca activation and inactivation. I_Ca activationis shifted to more positive values in CPVT vs WT cells, whereas inactivation of I_Ca is shifted to more hyperpolarized potential in CPVT cells compared with WT cells. D. Voltage dependence of I_Ca window current () display a bell-shaped voltage-dependence, however, the peak of is reduced in CPVT cells (continuous line) compared to WT cells (dashed line). * P<0.05 and ** P<0.005.