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. 2011 Jun 6;6(6):e20863. doi: 10.1371/journal.pone.0020863

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Fernández-Velasco et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inline graphic — A. Analyze of the patch clamped-Ca²⁺ sparks revealed that the average of Ca²⁺ sparks frequencies in CPVT cells (filled circles, n = 10) were significantly higher compared to WT cells (open circles, n = 3). * P<0.05. Right insets. Representative examples of line-scan images of Ca²⁺ sparks elicited by depolarizing step to −48 mV. B & C. BAPTA dialysates (B) and thapsigargin-treatment (C) eliminates the difference in between CPVT and WT cells. D. In presence of Ryanodol in the perfusion solution, is reduced in WT cells compared to control condition, shown as light gray line.

A. Analyze of the patch clamped-Ca²⁺ sparks revealed that the average of Ca²⁺ sparks frequencies in CPVT cells (filled circles, n = 10) were significantly higher compared to WT cells (open circles, n = 3). * P<0.05. Right insets. Representative examples of line-scan images of Ca²⁺ sparks elicited by depolarizing step to −48 mV. B & C. BAPTA dialysates (B) and thapsigargin-treatment (C) eliminates the difference in between CPVT and WT cells. D. In presence of Ryanodol in the perfusion solution, is reduced in WT cells compared to control condition, shown as light gray line.