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Barnase, Shiga-like toxin (SLT) and Pseudomonas toxin (ETA) are recognized by BCR due to the attached epitope with subsequent endosomal internalization followed by inhibition of protein synthesis via hydrolysis of cellular RNA, N-glycosylation of 28S rRNA or ADP-ribosylation of EF-2 respectively. In the case of Fc domain, targeted cell death occurs via antibody dependent cellular cytotoxicity (ADCC) or complement dependent cytotoxicity (CDC).
