Table 1. Mutation sequence of potential STAT3 binding sites.
Potential binding site 1 (-330∼-322) | Potential binding site 2 (+64∼+72) | |
Wide type | AATTTCCCTTAACTA | TCTTTCCACTAAAGT |
STAT3M1 | AATCGCCCTTGACTA | |
STAT3M2 | TCTCGCCACTGAAGT | |
Consensus sequence | 5’-TTMXXXDMA-3’, where D is A, G, or T and M is A or C. |
In bold is the consensus SIE motif, and the bold underlined letters correspond to the mutated bases from the SIE motif.