Table 3.

Copy Number Frequencies in AMD Patients and Controls

Gene	CN	Control n (%)	AMD n (%)	Unadjusted		Age-Adjusted
				OR (95% CI)	P	OR (95% CI)	P
CCR3	0	1 (1.3)	1 (1.1)	0.93 (0.06–15.21)	0.96	0.35 (0.01–9.15)	0.53
	1	3 (3.8)	5 (5.7)	1.56 (0.36–6.75)	0.56	1.03 (0.17–6.32)	0.98
	2	70 (88.6)	75 (86.2)	1.0	—	1.0	—
	3+	5 (6.3)	6 (6.9)	1.12 (0.33–3.83)	0.86	1.81 (0.38–8.62)	0.45
	Total	79	87	—	—	—	—
CFH	0	0 (0)	0 (0)	—	—	—	—
	1	4 (5.1)	1 (1.1)	0.22 (0.02–2.05)	0.19	0.10 (0.01–1.40)	0.09
	2	68 (86.1)	76 (87.4)	1.0	—	1.0	—
	3+	7 (8.9)	10 (11.5)	1.28 (0.46–3.54)	0.64	2.10 (0.57–7.71)	0.26
	Total	79	87	—	—	—	—
CX3CR1	0	0 (0)	0 (0)	—	—	—	—
	1	2 (2.0)	4 (3.1)	1.36 (0.24–7.64)	0.72	1.41 (0.23–8.62)	0.71
	2	73 (73.0)	107 (82.3)	1.0	—	1.0	—
	3+	25 (25.0)	19 (14.6)	0.52 (0.27–1.01)	0.05*	0.55 (0.25–1.21)	0.14
	Total	100	130	—	—	—	—
ERCC6	0	0 (0)	0 (0)	—	—	—	—
	1	1 (1.3)	2 (2.3)	1.81 (0.16,20.40)	0.63	1.94 (0.08,44.87	0.68
	2	78 (98.7)	86 (97.7)	1.0	—	1.0	—
	3+	0 (0)	0 (0)	—	—	—	—
	Total	79	88	—	—	—	—
HTRA1	0	0 (0)	0 (0)	—	—	—	—
	1	0 (0)	0 (0)	—	—	—	—
	2	74 (92.5)	82 (93.2)	1.0	—	1.0	—
	3+	6 (7.5)	6 (6.8)	0.90 (0.28–2.92)	0.86	1.98 (0.46–8.52)	0.36
	Total	80	88	—	—	—	—
VEGF	0	0 (0)	0 (0)	—	—	—	—
	1	0 (0)	0 (0)	—	—	—	—
	2	77 (96.3)	88 (100.0)	1.0	—	1.0	—
	3+	3 (3.8)	0 (0)	—	—	—	—
	Total	80	88	—	—	—	—
GSTM1	0	47 (58.8)	48 (54.5)	0.89 (0.46–1.72)	0.72	0.87 (0.40–1.91)	0.74
	1	0 (0)	2 (2.3)	—	—	—	—
	2	26 (32.5)	30 (34.1)	1.0	—	1.0	—
	3+	7 (8.8)	8 (9.1)	0.99 (0.32–3.10)	0.99	1.11 (0.29–4.33)	0.88
	Total	80	88	—	—	—	—
GSTT1	0	17 (21.3)	15 (17.4)	0.75 (0.31–1.83)	0.53	0.51 (0.18–1.45)	0.20
	1	39 (48.8)	38 (44.2)	0.83 (0.41–1.69)	0.61	0.82 (0.35–1.91)	0.64
	2	23 (28.8)	27 (31.4)	1.0	—	1.0	—
	3+	1 (1.3)	6 (7.0)	5.11 (0.57–45.57)	0.14	2.05 (0.18–23.94)	0.57
	Total	80	86	—	—	—	—

The frequencies of all CN categories were compared using unadjusted or age-adjusted logistic regression, with CN = 2 as the reference.

^*P = 0.05.