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. 2011 May 16;52(6):3200–3206. doi: 10.1167/iovs.10-6485

Figure 3.

Figure 3.

Effects of suppressing JNK on c-Jun and Plk3 activation. (A) Effect of hyperosmotic stress-induced Plk3 activation on c-Jun and ATF-2 phosphorylation. (B) Effect of hyperosmotic stress-induced JNK activation on c-Jun and ATF-2 phosphorylation. (C) Effect of hyperosmotic stress-induced p38 activation on c-Jun and ATF-2 phosphorylation. (D) Comparison of sensitivity of hyperosmotic stress-induced Plk3 activation in HCE and HTCE cells. (E) Effect of knocking down JNK mRNA on hyperosmotic stress-induced c-Jun phosphorylation. (F) Effect of knocking down JNK mRNA on hyperosmotic stress-induced Plk3 activity. (G) Effect of knocking down Plk3 mRNA on hyperosmotic stress-induced JNK activity. Phosphorylation of JNK and c-Jun was measured by using anti-phospho-JNK and anti-phospho-c-Jun antibodies, respectively. Plk3 activity was determined by immunocomplex kinase assay. Asterisk: significant differences in four independent sets of experiments.