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. 2011 May 20;52(6):3391–3397. doi: 10.1167/iovs.10-6165

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Figure 6. — Working model for the role of the miR-29 family in TGF-β2–mediated signaling. TGF-β2 stimulation activates SMAD3 signaling, which is necessary for both miR-29b expression and ECM induction by TGF-β2. Concurrently, TGF-β2 suppresses miR-29b levels by an unidentified molecular pathway dominant over that mediated by SMAD3 signaling. TGF-β2 stimulation also results in the induction of miR-29a expression. Together, the miR-29 family functions as an important modulator of ECM synthesis by TGF-β2.