Table 4.
Lipid Phase-Transition Parameters
| Phase-Transition Parameter | Normal (Age-Matched) | MGD | Significance (P) |
|---|---|---|---|
| Minimum frequency, cm−1 | 2849.90 ± 0.09 | 2849.68 ± 0.06 | 0.09 |
| Maximum frequency, cm−1 | 2853.6 ± 0.1 | 2853.48 ± 0.07 | 0.41 |
| Cooperativity | −9.2 ± 0.5 | −8.5 ± 0.4 | 0.40 |
| Phase transition | 28.9 ± 0.4 | 32.2 ± 0.5 | 0.002 |
| Temperature, °C | |||
| Enthalpy, kcal/mol | 180 ± 15 | 157 ± 7 | 0.15 |
| Entropy, kcal/mol/deg | 0.56 ± 0.05 | 0.51 ± 0.02 | 0.29 |
| Order % at 33.4°C | 35 ± 2 | 47 ± 2* | 0.004 |
| Donors, n | 13 | 49 |
*
Order values are predicated on meibum from 50 donors.